Analysis of Renal Pathology Predictors in Tender-Age Infants: Cohort Study

Background . The early onset of nephropathies creates certain risk chronic kidney disease development with loss function (especially in children unfavorable intrauterine period), renal tissue dysplasia, congenital malformations and/or urodynamic disorders. Objective aim the study is to evaluate role ontogenesis factors tender-age infants specification course features and kidneys morphometric parameters. Methods Cohort was conducted. group included 69 aged from 0 36 months changes (compared age-specific ones) according ultrasound urinary syndrome (leukocyturia, bacteriuria, proteinuria, etc.). control 35 relatively healthy same age. Comparative analysis antenatal postnatal medical history carried out both groups, as well comparison indicators system organs at neonatal screening. Pathological process also considered nephropathies. conducted during 2018–2021. Results Possible predictors pathology are: 1) maternal diseases: disorders (OR = 4.99), blood pathology, mainly anemia 2nd–3rd grade 6.94), cardiovascular diseases 10.26), inflammatory genital tract 10.61); 2) pregnancy failures: gestational diabetes mellitus 7.24), preeclampsia eclampsia 4.40); placental 17.0), fetoplacental insufficiency 7.61); 3) feeding features: conversion breast-milk substitutes 2.81). 50.7% this has shown persistent already first life data, signs bloated kidneys. It that manifestation associated aggravated perinatal defects occurs significantly earlier — 2 months, without any 4 (p 0.004). Conclusion Burdened negative effect on morphogenesis conditions for life.